Electron Imaging Center for NanoMachines

EICN provides advanced electron imaging tools for applications ranging from materials science to structural biology 

Electron Imaging Center for NanoMachines

Publications

Users of the EICN Laboratory are requested to acknowledge their use of the Technology Centers at CNSI in their scholarly publications. All publications listed here included data acquired or generated in the EICN Laboratory.

  • Xu X, Zhang Q, Hao M, Hu Y, Lin Z, Peng L, Wang T, Ren X, Wang C, Zhao Z, Wan C, Fei H, Wang L, Zhu J, Sun H, Chen W, Du T, Deng B, Cheng GJ, Shakir I, Dames C, Fisher TS, Zhang X, Li H, Huang Y, Duan X. “Double-negative-index ceramic aerogels for thermal superinsulation“. Science. 2019 Feb 15;363(6428):723-727. doi: 10.1126/science.aav7304. PMID:30765563
  • Mo R, Li F, Tan X, Xu P, Tao R, Shen G, Lu X, Liu F, Shen L, Xu B, Xiao Q, Wang X, Wang C, Li J, Wang G, Lu Y. “High-quality mesoporous graphene particles as high-energy and fast-charging anodes for lithium-ion batteries“. Nat Commun. 2019 Apr 1;10(1):1474. doi: 10.1038/s41467-019-09274-y. PMID: 30931924
  • Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. “Cryo-EM structures of four polymorphic TDP-43 amyloid cores.” Nat Struct Mol Biol. 2019 Jul;26(7):619-627. doi: 10.1038/s41594-019-0248-4. Epub 2019 Jun 24. PMID: 31235914
  • Liu Y, Huynh DT, Yeates TO. A 3.8 Å “Resolution cryo-EM Structure of a Small Protein Bound to an Imaging Scaffold.” Nat Commun. 2019 Apr 23;10(1):1864. doi: 10.1038/s41467-019-09836-0. PMID: 31015551
  • Zheng Q, Zhu R, Xu L, He M, Yan X, Liu D, Yin Z, Wu Y, Li Y, Yang L, Hou W, Li S, Li Z, Chen Z, Li Z, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS*, Cheng T*, Li S*, Xia N*. (2019) “Atomic Structures of Enterovirus D68 in Complex with Two Monoclonal Antibodies Define Distinct Mechanisms of Viral Neutralization“. Nat. Microbiol., 4:124-133. doi: 10.1038/s41564-018-0275-7.  Gao Y, Cui Y, Fox T, Lin S, Wang H, de val Alda N, Zhou, ZH and Yang W. (2019) Structures and operating principles of the replisome. Science, 363 (6429) pii: eaav7003 doi: 10.1126/science.aav7003. 
  • Si Z, Zhang J, Shivakoti S, Atanasov I, Tao CL, Hui WH, Zhou K, Yu X, Li W, Luo M, Bi GQ, Zhou ZH* (2018) “Different functional states of fusion protein gB Revealed on Human Cytomegalovirus by cryo electron tomography with Volta phase plate“. PLoS Pathog. 14(12):e1007452. doi: 10.1371/journal.ppat.1007452. PMCID: PMC6307773. 
  • Kerviel A, Ge P, Lai M, Jih J, Boyce M, Zhang X, Zhou ZH*, Roy P* (2019) “Atomic structure of the translation regulatory protein NS1 of bluetongue virus“. Nat. Microbio. PMID: 30778144 PMCID: PMC6482088
  • Liu W, Dai X, Jih J, Chan K, Trang P, Yu X, Balogun R, Mei Y, Liu F, Zhou ZH*. (2019) “Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development“. PLoS Pathog 15(2): e1007615. 
  • Liu, Y-T, Tao, C-L, Lau, P-M, Zhou, ZH, Bi, G-Q. (2019) “Postsynaptic Protein Organization Revealed by Electron Microscopy“. Curr. Opion. Struct. Biol., 54: in press.
  • Ding K, Chang T, Shen W, Roy P*, Zhou ZH* (2019) “In Situ Structures of Rotavirus Polymerase in Action and Mechanism of mRNA transcription and release.” Nat Commun. 10:2216. doi: 10.1038/s41467-019-10236-7
  • Pumroy, RA., Samanta, A., Liu, Y., Hughes, TET., Zhao, S., Yudin, Y., Huynh, KW., Zhou, ZH, Rohacs, T., Han, S., and Moiseenkova-Bell VY. (2019, Jan 16). Molecular mechanism of TRPV2 channel modulation by cannabidiolbioRxiv doi: 
  • Liu Y-T, Jih J, Dai X, Bi G-Q and Zhou ZH* (2019) “Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome“, Nature 570, 257–261
  • Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. “Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM”. Nat Struct Mol Biol. 2018 Jan;25(1):53-60. doi: 10.1038/s41594-017-0009-1. PubMed PMID: 29323279.
  • Ilyas M, Mietzsch M, Kailasan S, Väisänen E, Luo M, Chipman P, Smith JK, Kurian J, Sousa D, McKenna R, Söderlund-Venermo M, Agbandje-McKenna M. “Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy“. Viruses. 2018 Jan 4;10(1). pii: E22. doi: 10.3390/v10010022. PubMed PMID: 29300333; PubMed Central PMCID: PMC5795435.
  • Snijder J, Ortego MS, Weidle C, Stuart AB, Gray MD, McElrath MJ, Pancera M, Veesler D, McGuire AT. “An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus”Immunity. 2018 Apr 17;48(4):799-811.e9. doi: 10.1016/j.immuni.2018.03.026. PubMed PMID: 29669253; PubMed Central PMCID: PMC5909843.
  • Chen J, Zhu E, Liu J, Zhang S, Lin Z, Duan X, Heinz H, Huang Y, De Yoreo JJ. “Building two-dimensional materials one row at a time: Avoiding the nucleation barrier”. Science. 2018 Dec 7;362(6419):1135-1139. doi: 10.1126/science.aau4146. PMID: 30523105
  • Lin Z, Liu Y, Halim U, Ding M, Liu Y, Wang Y, Jia C, Chen P, Duan X, Wang C, Song F, Li M, Wan C, Huang Y, Duan X. “Solution-processable 2D semiconductors for high-performance large-area electronics”. Nature. 2018 Oct;562(7726):254-258. doi: 10.1038/s41586-018-0574-4. Epub 2018 Oct 3. PMID:
  • Yao B, Huang SW, Liu Y, Vinod AK, Choi C, Hoff M, Li Y, Yu M, Feng Z, Kwong DL, Huang Y, Rao Y, Duan X, Wong CW. “Gate-tunable frequency combs in graphene-nitride microresonators”. Nature. 2018 Jun;558(7710):410-414. doi: 10.1038/s41586-018-0216-x. Epub 2018 Jun 11.PMID:29892031
  • Liu Y, Guo J, Zhu E, Liao L, Lee SJ, Ding M, Shakir I, Gambin V, Huang Y, Duan X. “Approaching the Schottky-Mott limit in van der Waals metal-semiconductor junctions”. Nature. 2018 May;557(7707):696-700. doi: 10.1038/s41586-018-0129-8. Epub 2018 May 16. PMID: 29769729
  • Liu Z, Liu J, Wu HB, Shen G, Le Z, Chen G, Lu Y. “Iron-decorated nitrogen-rich carbons as efficient oxygen reduction electrocatalysts for Zn-air batteries”. Nanoscale. 2018 Sep 20;10(36):16996-17001. doi: 10.1039/c8nr04627a.
  • Lo YH, Zhao L, Gallagher-Jones M, Rana A, J Lodico J, Xiao W, Regan BC, Miao J. “In situ coherent diffractive imaging“. Nat Commun. 2018 May 8;9(1):1826. doi: 10.1038/s41467-018-04259-9.
  • White ER, Lodico JJ, Regan BC. “Intercalation events visualized in single microcrystals of graphite”. Nat Commun. 2017 Dec 6;8(1):1969. doi: 10.1038/s41467-017-01787-8. Erratum in: Nat Commun. 2018 Feb 19;9(1):759.
  • Chen NY, Kim P, Weston TA, Edillo L, Tu Y, Fong LG, Young SG. “Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures“. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10100-10105. doi: 10.1073/pnas.1812622115. Epub 2018 Sep 17
  • Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG. “Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome”. Sci Transl Med. 2018 Sep 26;10(460). pii: eaat7163. doi: 10.1126/scitranslmed.aat7163
  • Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P. “Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells”. Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13.
  • He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. “Macrophages release plasma membrane-derived particles rich in accessible cholesterol”. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8499-E8508. doi: 10.1073/pnas.1810724115. Epub 2018 Aug 20
  • Huynh KW, Jiang J, Abuladze N, Tsirulnikov K, Kao L, Shao X, Newman D, Azimov R, Pushkin A, Zhou ZH*, Kurtz I.* (2018) “CryoEM structure of the human sodium-coupled acid-base transporter NBCe1″Nature Communication. 9(1):900. doi: 10.1038/s41467-018-03271-3. PMCID: PMC5834491
  • Hughes TET, Lodowski DT, Huynh KW, Yazici A, Samanta A, Basak S, Zhou ZH, Rohacs T, Han S, Moiseenkova-Bell VY*. (2018) “Structural basis of the TRPV5 channel inhibition revealed by cryo-EM”Nat Struct Mol. Biol. 25(1):53-60. doi: 10.1038/s41594-017-0009-1. PMCID: PMC5951624
  • Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. (2018) “Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2“. Nat Struct Mol Biol. 25(4):311-319. doi: 10.1038/s41594-018-0045-5. PMID: 29531287
  • Dai X., Gong D., Lim H., Jih J., Wu T.T., Sun R.*, & Zhou Z.H.* (2018) “Structure and mutagenesis reveal capsid protein interactions essential to KSHV replication”Nature. 553:521-525. [Featured the “research highlights” section of Nature Chemical Biology, Vol. 14 2018 (p199)]  PMCID: PMC6039102  
  •  Ding, K, Zhang, X, Mrazek, J, Kickhoefer, VA, Lai, M, Ng, HL, Yang, OY, Rome, LH and Zhou, ZH*. (2018) “Solution structures of engineered vault particles“. Structure. 26(4):619-626.e3. doi: 10.1016/j.str.2018.02.014.
  • Dai X. & Zhou Z.H.* (2018) “Structure of the herpes simplex virus-1 capsid with associated tegument protein complexes“. Science. 360, 48, eaao7298. DOI: 10.1126/science.aao7298. PMCID: PMC5959011.
  • Park K, Kuo Y, Shvadchak V, Ingargiola A, Dai X, Hsiung L, Kim W, Zhou H, Zou P, Levine AJ, Li J, Weiss S (2018) “Membrane insertion of-and membrane potential sensing by-semiconductor voltage nanosensors: Feasibility demonstration“. Sci Adv. 4(1):e1601453. doi: 10.1126/sciadv.1601453  PMCID: PMC5770167
  • Tao CL, Liu YT, Sun R, Zhang B, Qi L, Shivakoti S, Tian CL, Zhang P, Lau PM, Zhou ZH*, Bi GQ*. (2018) “Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy”J Neurosci. 38(6):1493-1510. doi: 10.1523/JNEUROSCI.1548-17.2017. Epub 2018 Jan 8. PubMed PMID: 29311144; PubMed Central PMCID: PMC5815350.
  • Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, Gross ML, Leung DW, Chiu W*, Amarasinghe GK* (2018) “Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly”Cell. 2018 Feb 22;172(5):966-978.e12. doi: 10.1016/j.cell.2018.02.009.
  • Tian T, Li X, Liu Y, Wang C, Liu X, Bi G, Zhang X*, Yao X*, Zhou ZH*, Zang J*. “Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore”Cell Res. 2018 Mar;28(3):374-378. doi: 10.1038/cr.2018.13. Epub 2018 Jan 19. PubMed PMID: 29350209; PMCID: PMC5835772.
  • Kim MS, Chuenchor W, Chen X, Cui Y, Zhang X, Zhou ZH, Gellert M, Yang W. “Cracking the DNA Code for V(D)J Recombination”Mol Cell. 2018 Mar 29. pii: S1097-2765(18)30189-8.doi: 10.1016/j.molcel.2018.03.008. PMCID: PMC5987255
  • Jiang, J., Wang, Y., Susac, L., Chan, H., Basu, R., Zhou, Z.H.* and Feigon, J.* (2018) “Structure of telomerase with telomeric DNA”Cell. 173:1179-1190.e13. doi: 10.1016/j.cell.2018.04.038. PMCID: PMC5995583
  • Jiang J, Baiesc FL, Hiromasa Y, Yu X, Hui WH, Dai X, Roche TE, Zhou, ZH (2018) “Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex”Biochemistry, 57(16):2325-2334. doi: 10.1021/acs.biochem.8b00357. PMCID: PMC6033517. 
  • Tao CL, Liu YT, Zhou ZH, Lau PM,Bi GQ*. (2018) “Accumulation of dense core vesicles in hippocampal synapses following chronic inactivity“. Frontiers in Neuroanatomy. doi: 10.3389/fnana.2018.00048. eCollection 2018. PMCID: PMC6004418. 
  • Ho, C, Beck, JR, Lai, ML, Cui, Y, Goldberg, DE, Egea, PF*, Zhou, ZH* (2018) “Malaria parasite translocon structure and mechanism of effector export“. Nature, 561(7721):70-75. doi: 10.1038/s41586-018-0469-4.
  • Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer D, Ye S, Eisenberg DS*, Zhou ZH*, Jiang L* (2018) “Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel”Nat. Commun. 9(1):3609. doi: 10.1038/s41467-018-05971-2. PMCID: PMC6127345
  • Yu I, Nguyen L, Avaylon J, Wang K, Lai M and Zhou ZH. “Building atomic models based on near atomic resolution cryoEM maps with existing tools”J. Struct Biol. 2018 Nov;204(2):313-318. doi: 10.1016/j.jsb.2018.08.004.
  • Ding K, Nguyen L, Zhou ZH*. (2018) “In situ structures of polymerase complex and RNA genome show how aquareovirus transcription machineries respond to uncoating“. J Virol. 92(21). pii: e00774-18. doi: 10.1128/JVI.00774-18. PMCID: PMC6189512.
  • Zhu R, Xu L, Zheng Q, Cui Y, Li S, He M, Yin Z, Liu D, Li S, Li Z, Chen Z, Yu H, Que Y, Liu C, Kong Z, Zhang J, Baker TS, Yan X, Zhou ZH*, Cheng T*, Xia N* (2018) “Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10“. Sci. Adv.4(9):eaat7459. doi: 10.1126/sciadv.aat7459. 
  • Kappel K, Liu S, Larsen KP, Skiniotis G, Puglisi EV, Puglisi JD, Zhou ZH, Zhao R, Das R. (2018) “De novo computational RNA modeling into cryoEM maps of large ribonucleoprotein complexes”Nature Method. 15(11):947-954. doi: 10.1038/s41592-018-0172-2.
  • Liu S, Xu L, Guan F, Liu YT, Cui Y, Zhang Q, Zheng X, Bi GQ, Zhou ZH*, Zhang X*, Ye S* (2018) “Cryo-EM structure of the human α5β3 GABA(A) receptor“. Cell Res. 28(9):958-961. doi: 10.1038/s41422-018-0077-8. PMID:30140029; PMCID: PMC6123483.
  • Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY (2018) “Structural insights on TRPV5 gating by endogenous modulators”Nat Commun. 9(1):4198. doi: 10.1038/s41467-018-06753-6. PMCID: PMC6179994. 
  • Pittman N, Misseldine A, Geilen L, Halder S, Smith JK, Kurian J, Chipman P, Janssen M, Mckenna R, Baker TS, D’Abramo A Jr, Cotmore S, Tattersall P, Agbandje-McKenna M. “Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. Viruses“. 2017 Oct 30;9(11).pii: E321. doi: 10.3390/v9110321. PubMed PMID: 29084163; PubMed Central PMCID: PMC5707528. https://www.ncbi.nlm.nih.gov/pubmed/29084163
  • Walls AC, Tortorici MA, Snijder J, Xiong X, Bosch BJ, Rey FA, Veesler D. “Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion“. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11157-11162. doi: 10.1073/pnas.1708727114. Epub 2017 Oct 3. PubMed PMID: 29073020; PMCID: PMC5651768.
  • Sun H, Mei L, Liang J, Zhao Z, Lee C, Fei H, Ding M, Lau J, Li M, Wang C, Xu X, Hao G, Papandrea B, ShakirI, Dunn B, Huang Y, Duan X. “Three-dimensional holey-graphene/niobia composite architectures for ultrahigh-rate energy storage“. Science. 2017 May 12;356(6338):599-604. doi: 10.1126/science.aam5852. PMID: 28495745
  • Zhang X, Xu D, Jin X, Liu G, Liang S, Wang H, Chen W, Zhu X, Lu Y. “Nanocapsules of therapeutic proteins with enhanced stability and long blood circulation for hyperuricemia management“. J Control Release. 2017 Jun 10;255:54-61. doi: 10.1016/j.jconrel.2017.03.019. Epub 2017 Mar 11
  • Mayle KM, Dern KR, Wong VK, Sung S, Ding K, Rodriguez AR, Taylor Z, Zhou ZH, Grundfest WS, Deming TJ, Kamei DT. “Polypeptide-Based Gold Nanoshells for Photothermal Therapy“. SLAS Technol. (2017) 22(1):18-25. doi: 10.1177/2211068216645292.  PMID: 27126980  PMCID: PMC6070380
  • Dai, X, Li, X, Lai, M, Shu, S, Du, Y, Zhou, ZH* and Sun, R* (2017). “In situ structures of the genome and genome-delivery apparatus in an ssRNA virus“. Nature. 541(7635):112-116. doi: 10.1038/nature20589. *corresponding authors PMCID: PMC5701785
  • Yu, X, Jih, J, Jiang, J and Zhou, ZH* (2017) “Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150“, Science, 356. 1350. doi: 10.1126/science.aam6892. PMC5715728
  • Li J, He Q, Liu Y, Liu S, Tang S, Li C, Sun D, Li X, Zhou M, Zhu P, Bi G, Zhou Z, Zheng JS, Tian C.* “Chemical Synthesis of K34-Ubiquitylated H2B for Nucleosome Reconstitution and Single-Particle Cryo-Electron Microscopy Structural Analysis“. Chembiochem. 2017. 18(2):176-180. doi: 10.1002/cbic.201600551
  • Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH*, Zhao R*. (2017) “CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing”Nat Commun. 8(1):1035. doi: 10.1038/s41467-017-01241-9. PMID: 29051543
  • Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T, Zhou ZH, Yan X, Xia N.* (2017) “Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody”.  Nat Commun. 8(1):505. doi: 10.1038/s41467-017-00477-9.  PMID: 28894095  PMCID: PMC5593947
  • Liu YT, Jiang J, Bohannon KP, Dai X, Gant Luxton GW, Hui WH, Bi GQ, Smith GA, Zhou Z.H.*  (2017) A pUL25 dimer interfaces the pseudorabies virus capsid and tegument”. J Gen Virol. doi: 10.1099/jgv.0.000903. PMID: 29035172. PMCID: PMC5718256
  • Dai X, Wu L, Sun R, Zhou ZH.* (2017) “Atomic Structures of Minor Proteins VI and VII in the Human Adenovirus”J. Virol. pii: JVI.00850-17. doi: 10.1128/JVI.00850-17. PMID: 28978703 PMCID: PMC5709574
  • Alewijnse, B., Ashton, A. W., Chambers, M. G., Chen, S., Cheng, A., Ebrahim, M., Eng, E., J H Hagen, W., Koster, A. J., Lopez, C. S., Lukoyanova, N., Ortega, J., Renault, L., Reyntjens, S., Rice, W. J., Scapin, G., Schrijver, R., Siebert, A., Stagg, S. M., Grum-Tokars, V., Wright, E. R., Wu, S., Yu, Z., Zhou, Z.H., Carragher, B., and S Potter, C.* (2017). “Best practices for managing large CryoEM facilities”J Struct Biol 199(3): 225 – 236. PMID: 28827185. PMCID: PMC5605453
  • Sun Y, Wollenberg AL, O’Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ*. (2017) “Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels viaPolyion Complexation”J Am Chem Soc. 139(42):15114-15121. doi: 10.1021/jacs.7b08190. PMID: 28976744 NIHMSID978645
  • Mayle KM, Dern KR, Wong VK, Chen KY, Sung S, Ding K, Rodriguez AR, Knowles S, Taylor Z, Zhou ZH, Grundfest WS, Wu AM, Deming TJ, Kamei DT. (2017) “Engineering A11Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)-Targeted Photothermal Therapy“. SLAS Technol. 22(1):26-35. doi: 10.1177/2211068216669710
  • Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS*. (2017) “Monomeric ephrinB2 binding induces allosteric changes inNipah virus G that precede its full activation“. Nat Commun. 8(1):781. doi: 10.1038/s41467-017-00863-3. PMID: 28974687 PMCID:
  • Sathiyamoorthy K, Jiang J, Möhl BS, Chen J, Zhou ZH, Longnecker R, Jardetzky TS*. (2017) “Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies“. Proc Natl Acad Sci U S A. 114(41):E8703-E8710. doi: 10.1073/pnas.1704661114.  PMID: 28939750  PMCID:
  • Grintsevich, EE, Ge, P, Sawaya, MR, Yesilyurt, HG, Terman, HR*, Zhou, ZH*, Reisler, E* (2017) “Catastrophic disassembly of actin filaments via Mical-mediated oxidation”Nature Communication, 8:2183. Doi:10.1038/s41467-017-02357-8. PMCID: PMC5736627 
  • Liu S, Li X, Zhang L, Jiang J, Hill RC, Cui, Y, Hansen KC, Zhou ZH*, Zhao R*. (2017) “Structure of the yeast spliceosomal postcatalytic P complex“. Science. pii: eaar3462. doi: 10.1126/science.aar3462. 358(6368):1278-1283. PMCID: PMC5828012. PMID: 29146870
  • Walls AC, Tortorici MA, Frenz B, Snijder J, Li W, Rey FA, DiMaio F, Bosch BJ, Veesler D. “Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy“. Nat Struct Mol Biol. 2016 Oct;23(10):899-905. doi: 10.1038/nsmb.3293. Epub 2016 Sep 12. PubMed PMID:27617430; PubMed Central PMCID: PMC5515730.
  • Li M, Zhao Z, Cheng T, Fortunelli A, Chen CY, Yu R, Zhang Q, Gu L, Merinov BV, Lin Z, Zhu E, Yu T, Jia Q, Guo J, Zhang L, Goddard WA 3rd, Huang Y, Duan X. “Ultrafine jagged platinum nanowires enable ultrahigh mass activity for the oxygen reduction reaction”. Science. 2016 Dec 16;354(6318):1414-1419. Epub 2016 Nov 17. PMID: 27856847
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  • Jiang, JS, Chan, H, Cash, DD, Miracco, EJ, Loo, RRO, Upton, HE, Cascio, D, Johnson, RO, Collins, K, Loo, JA, Zhou, ZH, Feigon, J (2015) “Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions”. Science, 350:aab4070, doi:10.1126/science.aab4070. PMCID: PMC4687456
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  • Jurado, AR, Huang, CS, Zhang, X, Zhou, ZH, Tong, L (2015) “Structure and substrate selectivity of the 750-kDaα6β6 holoenzyme of geranyl-CoA carboxylase”Nature Commun, 6:8986, doi:10.1038/ncomms9986. PMCID: PMC4673880. 
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  • Wang, L.J. and Zhou, Z.H. (2014) “Seeing molecular interactions of large complexes by cryoEM at atomic resolution”American Laboratory, Jan/Feb issue, 23-25
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  • Kui, Y., Wills, E., Lim, H.Y., Zhou, Z.H. and Baines, J. (2014) “Association of herpes simplex virus pUL31 with capsid vertices and components of the capsid vertex specific complex”J.Virol., 88:3815-25. PMCID: PMC3993549  
  • Gurel, GS, Ge, P, Grintsevich, EE, Shu, R, Blanchoin, L, Zhou, ZH, Reisler, E, Higgs, HN (2014) INF2-mediated severing through actin filament encirclement and disruption. Curr. Biol., 24:156-64. PMCID: PMC3992431
  • Yan, X, Gardone, G, Zhang, X, Zhou, ZH, Baker, TS (2014) “Single particle analysis integrated with microscopy: a high-throughput approach for reconstructing icosahedral particles”J. Struct. Biol.186:8-18. PMCID: PMC4070310  
  • Zhou, ZH (2014) “Structures of viral membrane proteins by high-resolution cryoEM”Curr. Opin. Virol., 5C:111-119.
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  • Dai, X. and Zhou, Z.H. (2014) “Purification of herpesvirus virions and capsids”Bio-protocols, 4(15): e1193. http://www.bio-protocol.org/e1193
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  • Sathiyamoorthy, K, Jiang, J, Hu, Y, Rowe, CL, Möhl, BS, Chen, J, Jiang, W, Mellins, ED, Longnecker, R, Zhou, Z.H. and Jardetzky. TS (2014) “Assembly and architecture of the EBV B cell entry triggering complex”PLoS Pathogen, 10:e1004309. doi: 10.1371/journal.ppat.1004309. PMCID: PMC4140853
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  • Jiang, J., Miracco, E.J., Hong, K., Eckert, B., Chan, H., Cash, D.D., Min, B., Zhou, Z.H.*, Collins, K.*, Feigon, J.* (2013) “The architecture of Tetrahymena telomerase holoenzyme”, Nature, 496: 187-192. (highlighted by News and Views, Nature 496, 177-178 and covered by more than 40 popular magazines and reports). PMCID: PMC3817743.  *corresponding authors
  • Yu, X., Jin, L., Jih, J., Shih, C. and Zhou, Z.H. (2013) “3.5Å cryoEM structure of hepatitis B virus core assembled from full-length core protein”PLoS One, 8(9):e69729. doi: 10.1371/journal.pone.0069729. PMCID: PMC3765168.
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  • Lu, G., Ota, A., Ren, S., Franklin, S., Rau, C.D., Ping, P., Lane, T.F., Zhou, Z.H., Reue, K., Lusis, A.J., Vondriska, T., Wang, Y. (2013). “PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response”. Mol Metab. 2, 405-416.
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  • Hughes, L.C., Ralston, K.S., Hill, K.S., Zhou, Z.H. (2012) “Three-dimensional structure of the trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring”PLoS One, 7(1):e25700. PMCID: PMC3250385
  • Gopal, A., Zhou, Z.H., Knobler, C.M. and Gelbart, W.M. (2012) “Visualizing large RNA molecules in solution”RNA, 18(2), 284-299. PMCID: PMC3264915
  • Luo J, Obmolova G, Malia TJ, Wu SJ, Duffy KE, Marion JD, Bell JK, Ge P, Zhou ZH, Teplyakov A, Zhao Y, Lamb RJ, Jordan JL, San Mateo LR, Sweet RW, Gilliland GL. (2012) “Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure”J. Mol. Biol. 421:112-124. PMID: 22579623
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  • Zhou, Z.H. (2012) “Seeing Engineered Loops in a Gene Delivery Vehicle by cryoEM”Structure, 8, 1286-1288. PMCID: PMC3422559
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  • Jiang ZK, Koh SB, Sato M, Atanasov IC, Johnson M, Zhou ZH, Deming TJ, Wu L. (2012) “Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses”.J Control Release.166:75-85. PMID: 23247040.
  • Zhang, X., Guo, H., Jin, L., Miller, J.F., and Zhou, Z.H. (2012) “Atomic structure of Bordetellabacteriophage reveals a jellyroll fold in cement protein and a topologically distinct HK97-like fold in major capsid protein”Microscopy and Microanalysis 18:72-73. PMC Journal – In progress
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  • Liu, H., Wu. L. Zhou, Z.H.* (2011) “Model of the trimeric fiber of human adenovirus 5 and its interactions with the pentameric penton base by cryo-electron microscopy and bioinformatics”J. Mol. Biol., 406, 764-774. (featured on cover) PMCID: PMC3392045
  • Green, T.J., Rowse, M., Tsao, J., Kang, J., Ge, P., Zhou, Z.H. and Luo, M. (2011) “Access of RNA encapsidated in the nucleocapsid of vesicular stomatitis virus”J. Virol. 85, 2714-2722. PMCID: PMC3067934
  • Gangalum, RK, Atanasov, IC, Zhou, ZH, Bhat, SP (2011) “aB-crystallin is found in detergent resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells“.J. Biol. Chem. 286, 3261-3269. PMCID: PMC3030331
  • Yu, X., Shah, S., Lee, M., Dai, W., Lo, P., Britt, W., Zhu, H., Liu, F. and Zhou, Z. H. (2011) “Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirus“, J. Struct. Biol. 174, 451-460. PMCID: PMC3684277 
  • Zhou, Z. H. (2011) “Atomic resolution cryo electron microscopy of macromolecular complexes”AdvProtein Chem Struct Biol 82, 1-35. PMCID: PMC3698602
  • Yu, X., Ge, P., Jiang, J., Atanasov, I. and Zhou, Z. H. (2011) “Atomic model of CPV reveals the mechanism used by this single-shelled virus to economically carry out functions conserved inmultishelled reoviruses”Structure 19, 652-661. PMCID: PMC3405907 (featured on cover)
  • Chen, J., Sun, J., Atanasov, I., Ryazantsev, S. and Zhou, Z. H. (2011) “Electron tomography reveals polyhedrin binding and existence of both empty and full cytoplasmic polyhedrosis virus particles inside infectious polyhedra”J. Virol. 85, 6077-6081. PMCID: PMC3126316
  •  Meng, H., Yang, S., Li, Z., Xia, T., Chen, J., Ji, Z., Zhang, H., Wang, X., Lin, S., Huang, C., Zhou, Z. H., Zink, J. I. and Nel, A. E. (2011) “Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism”ACS Nano 5,4434-4447. PMCID: PMC3125420  
  • Ge, P. and Zhou, Z. H. (2011) “Hydrogen-bonding networks and RNA bases revealed by cryo electron microscopy suggest a triggering mechanism for calcium switches”Proc Natl Acad Sci USA 108, 9637-9642. PMCID: PMC3111329 
  • Buehler, D. C., Toso, D. B., Kickhoefer, V. A., Zhou, Z. H. and Rome, L. H. (2011) “Vaults engineered for hydrophobic drug delivery”Small. 7, 1432-1439. (featured on cover) PMID: 21506266
  • Yang, Z., Hu, W., Chen, K., Wang, J. Lux, R., Zhou, Z.H. and Shi, W. (2011) “Alanine 32 in PilA is important for PilA stability and type IV pili function in Myxococcus xanthus”Microbiology, 157, 1920-1928. PMCID: PMC3167889
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  • Toso, D.B., Henstra, A.M., Gunsalus, R.P. and Zhou, Z.H. (2011) “Structural, mass, and elemental analyses of storage granules in methanogenic archaeal cells”, Environmental Microbiology, 13, 2587-2599. PMCID: PMC21854518.
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  • Li, F., Ge, P., Hui, W. H., Atanasov, I., Rogers, K., Guo, Q., Osato, D., Falick, A. M., Zhou, Z. H. and Simpson, L. (2009) “Structure of the core editing complex (L-Complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria“, Proc Natl Acad Sci U S A 106,12306-12310. PMCID: PMC2708173.
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