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Electron Imaging Center for NanoMachines

EICN provides advanced electron imaging tools for applications ranging from materials science to structural biology

Electron Microscopy

Electron Imaging Center for NanoMachines

Peer-reviewed Journal Publications

2015

Huber RC, Ferreira, AS, Thompson R, Kilbride D, Knutson NS, Devi LS, Toso DB, Zhou ZH, Rubin Y, Schwartz BJ, Tolbert SH (2015) POLARON DYNAMICS. Long-lived photoinduced polaron formation in conjugated polyelectrolyte-fullerene assemblies. Science, 348: 1340-1343. [Full Text]

Ge P, Scholl, D, Leiman, PG, Yu, X, Miller, JF and Zhou ZH (2015) Atomic structures of a bactericidal contractile nanotube in its pre- and post-contraction states. Nature Struct Mol Biol. 22, 377-82. [Full Text]

Dai, X, Gong, D, Xiao, Y, Wu, T-T, Sun, R, Zhou, ZH (2015) CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi’s sarcoma-associated herpesvirus capsid. Proc. Natl. Acad. Sci. USA. 112:E649-56. PMCID: PMC4343125. [Full Text]

Clemens, DL, Ge, P, Lee, B-Y, Horwitz, MA and Zhou, ZH (2015) Atomic structure of a T6SS reveals interlaced array essential to function. Cell, 160:940-51. doi: 10.1016/j.cell.2015.02.005. PMCID:PMC4351867 [Full Text]

Jiang, J, Pentelute, BL, Collier, RJ and Zhou, ZH (2015) Atomic structure of anthrax PA pore elucidates toxin translocation. Nature. 521:545-549 [Full Text]

Dejnirattisai, W, Wongwiwat, W, Supasa, S, Jumnainsong, A, Zhang, X., Dai, X., Rouvinsky, A, Jumnainsong, A, Edwards, C, Quyen, NTH, Duangchinda, T, Grimes, JM, Tsai, W-Y, Lai, C-Y, Wang, W-K, Malasit, P, Farrar, J, Simmons, CP, Zhou, ZH, Rey, FA, Mongkolsapaya, J, Screaton, GR (2015) A new class of highly potent broadly neutralizing antibodies isolated from dengue viremic patients. Nature Immunology, 16:170–177. [Full Text]

2014

Ge P, Durer ZA, Kudryashov D, Zhou ZH, Reisler E. (2014) Cryo-EM reveals different coronin binding modes for ADP- and ADP-BeFx actin filaments. Nat Struct Mol Biol. 21:1075-81. PMCID:PMC4388421 [Full Text]

Mrazek J, Toso D, Ryazantsev S, Zhang X, Zhou ZH, Fernandez BC, Kickhoefer VA, Rome LH (2014) Polyribosomes Are Molecular 3D Nanoprinters That Orchestrate the Assembly of Vault Particles. ACS Nano. 8, 11552-9. PMCID:PMC4245718 (Cover) [Full Text]

Buehler DC1, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. (2014) Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. ACS Nano. 8(8):7723-32. (featured on cover). PMCID:PMC4148163 [Full Text]

Sathiyamoorthy, K, Jiang, J, Hu, Y, Rowe, CL, MU+00F6hl, BS, Chen, J, Jiang, W, Mellins, ED, Longnecker, R, Zhou, Z.H. and Jardetzky. TS (2014) Assembly and architecture of the EBV B cell entry triggering complex. PLoS Pathogen, 10:e1004309. doi: 10.1371/journal.ppat.1004309. PMCID: PMC4140853 [Full Text]

Dai, X., Gong, D., Wu, T., Sun, R. and Zhou, Z.H. (2014) Organization of capsid-associated tegument components in Kaposi’s sarcoma-associated herpesvirus. J. Virol., 88: 12694-702. PMCID: PMC4248902 [Full Text]

Dai, X. and Zhou, Z.H. (2014) Purification of herpesvirus virions and capsids. Bio-protocols, 4(15): e1193. [Full Text]

Zhou, ZH, Hui, WH, Shah, S, Jih, J, O’Connor, CM, Sherman, MB, Kedes, DH, Schein, S (2014) Four levels of hierarchical organization including non-covalent chainmail brace the mature tumor herpesvirus capsid against pressurization, Structure, 22:1385-98 PMCID: PMC4433476 [Full Text]

Zhou, ZH (2014) Structures of viral membrane proteins by high-resolution cryoEM. Curr. Opin. Virol., 5C:111-119. [Full Text]

Yan, X, Gardone, G, Zhang, X, Zhou, ZH, Baker, TS (2014) Single particle analysis integrated with microscopy: a high-throughput approach for reconstructing icosahedral particles. J. Struct. Biol. 186:8-18. PMCID: PMC4070310 [Full Text]

Gurel, GS, Ge, P, Grintsevich, EE, Shu, R, Blanchoin, L, Zhou, ZH, Reisler, E, Higgs, HN (2014) INF2-mediated severing through actin filament encirclement and disruption. Curr. Biol., 24:156-64. PMCID: PMC3992431 [Full Text]

Kui, Y., Wills, E., Lim, H.Y., Zhou, Z.H. and Baines, J. (2014) Association of herpes simplex virus pUL31 with capsid vertices and components of the capsid vertex specific complex, J.Virol., 88:3815-25. PMCID: PMC3993549 [Full Text]

Ge, P. and Zhou, Z.H. (2014) Chaperone fusion proteins aid entropy-driven maturation of class II viral fusion proteins, Trends Microbiol, 22:100-106. PMID: 24380727 [Full Text]

Wang, L.J. and Zhou, Z.H. (2014) Seeing molecular interactions of large complexes by cryoEM at atomic resolution. American Laboratory, Jan/Feb issue, 23-25 [Full Text]

2013

Zhang, X. Guo, H., Jin L., Czornyj E., Hodes, A., Hui, W.H., Nieh, A.W., Miller, J.F. and Zhou, Z.H. (2013) A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5Å resolution. eLife, 2:e01299. Doi: 107554/eLife.01299. PMCID: PMC3863775. [Full Text]

Hui WH, Tang Q, Liu H, Atanasov I, Liu F, Zhu H, Zhou ZH. (2013) Protein interactions in the murine cytomegalovirus capsid revealed by cryoEM, Protein Cell, 4, 833-45. doi: 10.1007/s13238-013-3060-7 [Full Text]

Lu, G., Ota, A., Ren, S., Franklin, S., Rau, C.D., Ping, P., Lane, T.F., Zhou, Z.H., Reue, K., Lusis, A.J., Vondriska, T., Wang, Y. (2013). PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab. 2, 405-416. [Full Text]

Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K (2013) Tetrahymena Telomerase Holoenzyme Assembly, Activation, and Inhibition by Domains of the p50 Central Hub. Mol Cell Biol., 33(19):3962-71. PMC3811867 [Full Text]

Dai, X., Yu, X., Gong, H., Jiang, X., Abenes, G., Liu, H., Shivakoti, S., Britt, W.B., Zhu, H., Liu, F. and Zhou, Z.H. (2013) The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus, PLoS Pathog9(8): e1003525. doi:10.1371/journal.ppat.1003525. PMCID: PMC3744435 [Full Text]

Yu, X., Jin, L., Jih, J., Shih, C. and Zhou, Z.H. (2013) 3.5Å cryoEM structure of hepatitis B virus core assembled from full-length core protein,PLoS One, 8(9):e69729. doi: 10.1371/journal.pone.0069729. PMCID: PMC3765168. [Full Text]

Jiang, J., Miracco, E.J., Hong, K., Eckert, B., Chan, H., Cash, D.D., Min, B., Zhou, Z.H., Collins, K., Feigon, J. (2013) “The architecture of Tetrahymena telomerase holoenzyme”, Nature, 496: 187-192. (highlighted by News and Views, Nature 496, 177-178 and covered by more than 40 popular magazines and reports). PMCID: PMC3817743 [Full Text]

Jiang J, Magilnick N, Tsirulnikov K, Abuladze N, Atanasov I, Ge P, Narla M, Pushkin A, Zhou ZH, Kurtz I. (2013) Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains. PLoS One. 8(2):e55408. doi: 10.1371/journal.pone.0055408. PMCID: PMC3564912. [Full Text]

Slaymaker IM, Fu Y, Toso DB, Ranatunga N, Brewster A, Forsburg SL, Zhou ZH, Chen XS. (2013) Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. Nucleic Acids Res. 41: 3446-3456. PMCID: PMC3597688 [Full Text]

Zhang, X., Ge, P., Yu, X., Brannan, J.M., Bi, G., Zhang, Q., Schein, S. and Zhou, Z.H. (2013) Cryo-EM structure of the mature dengue virus at 3.5Å resolution. Nature Mol. Struct. Biol., 20: 105-110. PMCID: PMC3593067 [Full Text]

2012

Zhang, X., Guo, H., Jin, L., Miller, J.F., and Zhou, Z.H. (2012) Atomic structure of Bordetella bacteriophage reveals a jellyroll fold in cement protein and a topologically distinct HK97-like fold in major capsid protein. Microscopy and Microanalysis 18:72-73. PMC Journal [Full Text]

Jiang ZK, Koh SB, Sato M, Atanasov IC, Johnson M, Zhou ZH, Deming TJ, Wu L. (2012) Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses. J Control Release.166:75-85. PMID: 23247040. [Full Text]

Xiao Q, Sohn H, Chen Z, Toso D, Mechlenburg M, Zhou ZH, Poirier E, Dailly A, Wang H, Wu Z, Cai M, Lu Y. (2012) Mesoporous metal and metal alloy particles synthesized by aerosol-assisted confined growth of nanocrystals. Angew Chem Int Ed Engl. 51:10546-10550. PMID: 23001891 [Full Text]

Zhou, Z.H. (2012) Seeing Engineered Loops in a Gene Delivery Vehicle by cryoEM. Structure, 8, 1286-1288. PMCID: PMC3422559 [Full Text]

Tao, C, Xia, C, Chen, X, Zhou, ZH, Bi, G (2012) Ultrastructural analysis of neuronal synapses using state-of-the-art nano-imaging techniques,Neurosci Bull. 28, 321-332. [Full Text]

Huang, C.S., Ge., P., Zhou, Z.H. and Tong, L. (2012) An unanticipated architecture of the 750 kD ?6?6 holoenzyme of 3-methylcrotonyl-CoA carboxylase, Nature, 481, 219-223. [Full Text]

Hughes, L.C., Ralston, K.S., Hill, K.S., Zhou, Z.H. (2012) Three-dimensional structure of the trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. PLoS One, 7(1):e25700 [Full Text]

Jinquan Luo, Galina Obmolova, Thomas J. Malia, Sheng-Jiun Wu, Karen Duffy, James D. Marion, Jessica K. Bell, Peng Ge, Z. Hong Zhou, Alexey Teplyakov, Yonghong Zhao, Roberta Lamb, Jarrat Jordan, Lani San Mateo, Raymond W. Sweet, Gary L. Gilliland (2012) Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure. J. Mol. Biol. ( PMID: 22579623)    [Full Text]  

Gopal, A., Zhou, Z.H., Knobler, C.M. and Gelbart, W.M. (2012) Visualizing large RNA molecules in solution. RNA, 18(2), 284-299 [Full Text]